The Cottagers are aiming to bounce back after defeat to local rivals Chelsea, with Mason Mount’s strike breaking their spirited display after going down to 10 men following Antonee Robinson’s red card in the first half.
While Ole Gunnar Solskjaer will hope his side can prove to be more effective in the final third this week, despite a valuable point at the home of the champions on Sunday. Meanwhile, Scott Parker insists he is thrilled by his side’s fight last time out.
"We've done remarkably well considering where we were at the start of the season," said Parker. "We were probably the laughing stock in terms of how people were portraying us - never was that the case in-house. We've done remarkably well to be fighting and punching away like we are - not just with determination and grit, but with a real style about us.
"It's clear that you can see a real drastic improvement in our overall game. There was a narrative around us at the start of this season and that narrative was probably helped by the previous time we were in this division. We lost two games by more than two goals, that narrative was instantly in people's heads, 'Oh look, it's the same Fulham'.
“I just think people were blurred a little bit by the last time we were here. I can understand why. It was certainly an area we needed to address.”
Here’s everything you need to know ahead of the match:
When is the match?
The game takes place on Wednesday, 20 January and kicks off at 20:15 GMT.
Where can I watch it?
The match will be shown live on BT Sport 1 and BT Sport Ultimate. The game can also be streamed via the BT Sport app and desktop website. Coverage begins at 8pm GMT, following the conclusion of Man City vs Aston Villa.
Fulham: Areola; Adarabioyo, Andersen, Aina; Bryan, Reed, Zambo Anguissa, Tete; Loftus-Cheek, Lookman; Cavaleiro
Manchester United: De Gea; Wan Bissaka, Bailly, Maguire, Shaw; Fred, Pogba; Greenwood, Fernandes, Martial; Cavani
Fulham - 5/1
Draw - 10/3
Manchester United - 1 / 2
United picked up a valuable point at the champions last time out, but that result is only useful if they back it up with a victory here. Fulham’s promising run of five successive draws came to an end against Chelsea, but Scott Parker’s side battled hard there, and I expect them to do so once again, despite a couple of key losses through suspension. Ultimately we’ll lean towards United’s match-winners grinding out the three points for Ole Gunnar Solskjaer though, perhaps with the winner coming in the final 15-20 minutes or so with plenty of firepower off the bench to take advantage of any tired Fulham legs. Fulham 1-2 Man United.