The striker missed Wednesday’s draw at Tottenham after tweaking a muscle during Saturday’s FA Cup win over QPR.
Mitrovic, however, has since trained and could return to the squad - but midfielders Tom Cairney and Mario Lemina are still out.
“Mitrovic is possible to be there for the weekend,” said Parker.
“He trained today - lightly - and we will see how he pulls through tomorrow. Then the other two boys (Cairney and Lemina) are just not available at the moment. Tom has got an issue with his knee.”
Saturday’s trip to Chelsea will be Fulham’s second match in four days and it may mean Scott Parker has to make some changes.
Ruben Loftus-Cheek cannot play as he is on loan from Chelsea and Ademola Lookman - who impressed off the bench against Spurs - is one player pushing for a start.
Fulham predicted XI (3-5-2): Areola; Aina, Andersen, Adarabioyo; Tete, Reid, Reed, Zambo, Robinson; Cavaleiro, Lookman
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