12 years have now passed since that fateful quarter-final tie in South Africa, when Luis Suarez was sent off for preventing a certain winning goal with a handball on the line in the dying seconds of extra-time, only for Asamoah Gyan to miss the resulting penalty and Ghana to fall in heartbreaking fashion in the shootout.
Ghanaian fans still hold plenty of animosity for that divisive act from Suarez hailed as villainous in some parts and genius in others, which adds extra spice to a key clash in the final round of Group H fixtures.
A revenge win here would be enough for the Black Stars to reach the last 16 for the third time since 2006, while a draw would also be okay if South Korea do not beat Portugal.
Uruguay, meanwhile, are in must-win mode after following a stalemate against Korea with a defeat by the Portuguese, with anything less resulting in elimination. They need all three points and a favour from Cristiano Ronaldo and Co in Al Rayyan.
Date, kick-off time and venue
Ghana vs Uruguay is scheduled for a 3pm GMT kick-off today, December 2, 2022.
The match will take place at Al Janoub Stadium in Al Wakrah, Qatar.
Where to watch Ghana vs Uruguay
TV channel: In the UK, the match will be televised free-to-air and live on BBC Two, with coverage beginning at 2:45pm.
Live stream: Fans can also catch the game live online via the BBC iPlayer and BBC Sport website.
Live blog: You can follow all the action on matchday via Standard Sport’s live blog.
Ghana vs Uruguay team news
Ghana defender Gideon Mensah has insisted that he will be fit for Friday’s game after being taken off late on in the thrilling 3-2 win over South Korea, revealing he was just suffering from cramp.
Mensah had been drafted in to replace Chelsea’s Reading loanee Baba Rahman at left-back.
For Uruguay, it will be interesting to see if Suarez features against the team that probably dislikes him the most, having been dropped to the bench and restricted to a late substitute’s cameo against Portugal, with Edinson Cavani starting alongside Darwin Nunez up top instead.
Key defender Ronald Araujo has yet to feature at this tournament due to having recently undergone thigh surgery and reports suggest Uruguay and Barcelona are not in accord over his recovery.
Ghana vs Uruguay prediction
Ghana have been huge entertainment value at this World Cup so far, outlasting Korea after just missing out against Portugal in another five-goal thriller.
Drama, goals and action aplenty seems guaranteed whenever Otto Addo’s side are involved, though will that still be the case against Uruguay?
La Celeste have yet to score a single goal at this tournament and have put in two very lacklustre performances indeed.
But with three points an absolute necessity, they could well let the handbrake off here and show their quality.
Uruguay to win, 2-1.
Head to head (h2h) history and results
The aforementioned World Cup quarter-final at Soccer City in 2010 was the only previous meeting between these two nations.
Ghana wins: 0
Uruguay wins: 1
Ghana vs Uruguay match odds
Ghana win: 4/1
Uruguay win: 8/11
Odds via Betfair (subject to change).