Quins are currently sat fourth in the Premiership and are hoping to make the semi-finals for the first time since 2014.
As a result, they rested a host of players for their Challenge Cup quarter-final with Ulster on April 4 and lost 21-57.
The likes of Danny Care and Mike Brown have now been recalled, though, for Saturday’s game with Worcester.
Joe Marler starts at prop in what is a formidable looking front row, with Wilco Louw scrumming down on the other side.
Alex Dombrandt returns to the back row and will captain the side in the absence of the injured Stephan Lewies.
In the backs, Marcus Smith returns at fly-half, while Andre Esterhuizen and Joe Marchant are paired together in the centres.