In one of the ties of the round, Inter Milan take on Bayer Leverkusen for a place in the Europa League semi-finals.
Antonio Conte will look to put a terbulent few weeks behind him, with the Italian publicly voicing his discontent at the club, sparking speculation he could leave.
There will be no shortage of talent on display here; from Romelu Lukaku to Kai Havertz and Moussa Diaby to Lautaro Martinez.
The winner will be highly fancied to go all the way in Germany.
Here is how you can watch the game live on television or through a live stream.
When is it and what time is kick-off?
The match will begin at 8pm BST on Monday 10 August at the Esprit Arena, in Dusseldorf, Germany.
How can I watch it online and on TV?
The game will be broadcast live on BT Sport 2. Coverage starts at 19:45.
Subscribers can also stream the match on the BT Sport website and app.
Inter XI: Handanovic; Godin, De Vrij, Bastoni; D'Ambrosio, Barella, Brozovic, Gagliardini, Young; Lukaku, Lautaro Martinez
Leverkusen XI: Hradecky; Wendell, S. Bender, Tah, L. Bender; Baumgartlinger, Dermibay, Palacios; Diaby, Volland, Havertz
Inter Milan 21/20
Bayer Leverkusen 13/5