The reigning NFL rushing champion, Taylor has tallied 328 yards and a touchdown through four games. He has added nine catches for 44 yards. Nyheim Hines is next up on the Colts' running back depth chart.
Taylor's per-game rushing average has dropped from 106.5 yards last season to 82 in 2022 while his per-carry average has dropped from 5.5 yards to 4. His struggles coincide with a sluggish Colts offense helmed by first-year quarterback Matt Ryan that's produced a league worst 14.3 points per game through four weeks. They were shut out in Week 2 against the Jacksonville Jaguars.
A Colts team that was expected to compete for the AFC South is 1-2-1.
Colts down multiple key players vs. Broncos
The Colts will also be without their best defender against the Broncos. Head coach Frank Reich announced on Monday that All-Pro linebacker Shaquille Leonard won't play after sustaining a concussion Sunday. He remains in concussion protocol, as does backup defensive end Tyquan Lewis.
Starting safety Justin Blackmon will also miss Thursday's game with an ankle injury.