Leeds beat 3-0 Southampton last time out, and also hammered Villa 3-0 earlier in the season when Patrick Bamford scored a hat-trick.
Only one points separates the two sides, who are both in the top half and looking to push up towards the European places.
Jack Grealish remains out for Villa, while Leeds are missing midfield lynchpin Kalvin Phillips.
Here is everything you need to know.
When is the game?
Leeds vs Aston Villa kicks off today at 5.30pm GMT.
How can I watch it?
The match will be broadcast live on Sky Sports in the UK, and subscribers can stream online via the Sky Sports website and the Sky Sports app.
What is the team news?
Leeds midfielder Mateusz Klich may miss out through injury. Rodrigo and Kalvin Phillips remain out while Robin Koch is not expected to return for another week.
Jack Grealish remains out with a shin injury, while Matty Cash, Kortney Cause and Wesley also remain injured.
Leeds United: Meslier, Ayling, Cooper, Llorente, Dallas, Raphinha, Struijk, Klich, Costa, Roberts, Bamford
Aston Villa: Martinez, Elmohamady, Konsa, Mings, Targett, McGinn, Nakamba, Ramsey, El Ghazi, Traore, Watkins
Aston Villa 11/5
Leeds hammered Villa last time these two met, and without Jack Grealish this could be an uphill battle for the visitors once more. Leeds 2-1 Villa.