With that in mind, it is perhaps a blessing in disguise that this “home” leg is being played across the continent at a neutral venue in Budapest because of current coronavirus travel restrictions.
Despite their domestic struggles, Jurgen Klopp’s side will be warm favourite to advance, having won the first leg 2-0 last month.
Date, kick-off time and venue location
Liverpool vs RB Leipzig is scheduled for an 8pm GMT kick-off on Wednesday, March 10, 2021.
The game will be played behind closed doors at the Puskas Arena in Budapest because of coronavirus restrictions.
Where to watch Liverpool vs RB Leipzig
TV channel: The match will be televised on BT Sport.
Live stream: BT Sport subscribers will be able to watch the match online via the website or BT Sport app.
Liverpool vs RB Leipzig team news
Liverpool were without forward Roberto Firmino for the defeat to Fulham, but will hope to have the Brazilian fit again, with his absence put down to a “minor knock”.
January signing Ozan Kabak also missed the game and is a doubt, but the likes of Sadio Mane, Fabinho and Trent Alexander-Arnold all started on the bench and should come back in.
Liverpool vs RB Leipzig lineups
Liverpool XI: Alisson; Alexander-Arnold, Fabinho, Phillips, Robertson; Jones, Thiago, Wijnaldum; Salah, Jota, Mane
RB Leipzig XI: Gulacsi; Mukiele, Upamecano, Klostermann; Adams, Sabitzer, Kampl, Olmo, Halstenberg; Sorloth, Nkunku
Liverpool vs RB Leipzig prediction
Liverpool’s confidence is understandably shot but the Champions League now takes on even greater precedence in their season and could provide a welcome break from their domestic struggles.
A draw would see them comfortably through to the last-eight.
1-1 draw, Liverpool to progress
Liverpool vs RB Leipzig head to head (h2h) results
The first leg between the two sides, which Liverpool won 2-0, is their only previous meeting.
Liverpool vs RB Leipzig odds and betting tips
Liverpool to qualify: 2/13
RB Leipzig to qualify: 6/1
Leipzig to win 1-0: Between 13/1 and 14/1
Odds via Betfair Exchange (subject to change). Click here to find out more.