The Reds’ summer signing Thiago has not featured since being hurt in the Merseyside derby in October and is now expected to be out until the New Year with a knee injury suffered in a challenge from Everton’s Richarlison.
Number one goalkeeper Alisson is also absent with a tight leg muscle, meaning Caoimhin Kelleher starts ahead of Adrian.
Jurgen Klopp has also provided an update on Virgil van Dijk’s recovery, saying the Dutchman’s knee “doesn’t look like a knee should” after surgery to repair ligament damage suffered in that same game at Goodison Park.
Van Dijk is likely to miss the remainder of the 2020/21 season, while Liverpool also remain without Naby Keita, Joe Gomez, Alex Oxlade-Chamberlain and Xherdan Shaqiri.
England right-back Trent Alexander-Arnold is progressing well with his rehab from a calf issue, though is not ready to return yet.
James Milner will also miss the visit of Ajax in Group D, having sustained a hamstring injury in Saturday’s 1-1 draw at Brighton.
Captain Jordan Henderson returned from injury at half-time at the Amex and should start on Tuesday as Liverpool look to avoid defeat and secure qualification for the last 16 of Europe’s elite club competition.
Liverpool XI: Kelleher, Neco Williams, Matip, Fabinho, Robertson, Jones, Wijnaldum, Henderson, Jota, Salah, Mane
Subs: Firmino, Adrian, Minamino, Tsimikas, Origi, Rhys Williams, Jaros, Cain, Clarkson
Ajax XI: Onana, Mazraoui, Schuurs, Blind, Tagliafico, Alvarez, Klaassen, Gravenberch, Antony, Tadic, Neres
Subs: Stekelenburg, Timber, Klaiber, Huntelaar, Promes, Scherpen, Ekkelenkamp, Labyad, Martinez, Traore
Referee: Tobias Stieler