After racking up a monster 7-1 lead from the morning session, Maguire took all four pre-intermission frames to move within two more of the last four.
And though Hendry worked his way to pulling the 13th frame back, his fellow Scotsman finished the job with the next two frames to end the contest a full session and a frame early.
Hendry, who produced a 147 maximum before going on to knock out defending champion John Higgins in the last 16, announced his retirement following the resounding defeat.
Breaks of 67, 72 and 68 showed 'On Fire' Maguire's intent to pick up where he had left off from the first session, and Hendry sported a wry smile as Maguire whitewashed the opening half-session with a fantastic 125.
Hendry mustered no more than a 39 en route to finally recording his second frame of the match, but he held firm on the final colours to see it through before Maguire put the match out of reach.
Runs of 61 and 45 provided the foundations of the two frames which confirmed the China Open runner-up as the first man to reach the one-table set-up at the Crucible.
And Hendry, arguably the greatest player in the history of the sport, announced in the post-match press conference that it was his final appearance at the famous venue which he dominated in the 1990s.
Stephen Maguire opened up a big advantage on fellow Scot Stephen Hendry with a 7-1 lead after the opening session of their World Championship quarter-final at The Crucible.
A host of uncharacteristic misses from the seven-times former title-holder allowed Maguire to edge his way to a four-frame whitewash heading into the mid-session interval, while Hendry cut a despondent figure on his seat.
And the China Open finalist turned up the heat in three of the remaining four frames with a 117, 60 and 95 while the 43-year-old managed to take his only frame of the morning with a solid break of 65 in the seventh.
Maguire took several visits over the opening two frames, making no break higher than 41, to take control in the all-Scottish quarter final with Hendry looking nervy and uncertain at the table.
And though the legendary veteran had a chance to clear up after another pair of Maguire mini-runs in the third, he missed the final pink by a shocking distance which allowed his namesake to clean up for 3-0.
A crucial miss on a simple black helped cost Hendry the fourth as Maguire took over with a 68, before a thumping 117 and a pair of runs at 17 and 60 put him a resounding six frames to the good with talk of a possible whitewash growing.
Hendry finally sprung into action with a 65 to kill off that possibility but succumbed to Maguire's assured and efficient 95 to find his hopes of a fairytale additional World crown in deep trouble.
Maguire can book a place in the semi-finals with a session to spare if he is able to win six of the eight frames in the evening's second session.