Pep Guardiola's champions sit 14 points behind Liverpool having played a game more, but Man City will be hoping that rivals Manchester United can do them a favour at Anfield this weekend.
As for Palace, Roy Hodgson will be looking to cause another Etihad shock having won 3-2 there in December 2018.
Date: Saturday, 18 January 2020
Kick-off time: 3pm GMT
Venue: Etihad Stadium, Manchester
Prediction: Man City 2-0 Crystal Palace
The Eagles are soaring in ninth place in the table, While they boast an impressive defensive record with 24 goals conceded, they have only scored 20 - and with City already scoring 62 this term, a home win is on the cards.
For Manchester City vs Crystal Palace ticket information, click here to head to City's official website.
Palace away tickets are currently unavailable.
TV channel: The match will be not be televised live in the UK due to TV blackout restrictions regarding 3pm kick-offs.
Live stream: You can follow the action on our rolling match blog.
Head to head (H2H) history
Premier League games: 19
Man City wins: 12
Palace wins: 3
Man City have won the last two League meetings - but the last time Palace visited the Etihad, they won 3-2 back in December 2018, with Andros Townsend scoring the Premier League goal of the season.
Man City to win: 1/8
Palace to win: 29/1
Draw: Between 11/1 and 12/1
Top tip: 2-0 City win - 15/2
Odds provided by Betfair Exchange. Click here for more odds.
Odds correct as of January 17.
Man City: Guardiola's squad have a clean bill of health save for Aymeric Laporte (knee) and Leroy Sane (knee), who are both edging their way back to fitness.
Palace: The Eagles are still in the midst of an injury crisis, with Andros Townsend (groin), Jeff Schlupp (groin), Joel Ward (knee), Scott Dann (calf), Patrick van Aanholt (thigh), Mamadou Sakho (thigh) and Max Meyer (ankle) out, along with the suspended Luka Milivojevic.
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