United have drawn a blank in their last three games - all 0-0 draws - with the goals drying up of late.
The absence of Paul Pogba has left United relying on Bruno Fernandes and Marcus Rashford for inspiration, but Solskjaer’s key men have looked tired of late and could do with a rest - but they won’t get one this weekend.
United head to the Etihad to face a Manchester City side who have won their last 21 matches in all competitions; a game that looked like a potential title-decider a few weeks ago is now a game the Red Devils need something from to avoid being sucked back down into a top-four fight.
Edinson Cavani returned from injury to lead the line on Thursday night at Crystal Palace but was a no-show as the squad arrived at the Lowry Hotel on Saturday evening, meaning Anthony Martial should lead the line.
With few other options in attack beyond young duo Amad Diallo and Shola Shoretire, Dan James could come in on the right flank for Mason Greenwood, with Fernandes in the middle and Rashford on the left.
Scott McTominay also returned at Selhurst Park and should partner Fred in midfield, while Victor Lindelof is a doubt with a recurring back problem but is expected to start alongside Harry Maguire at centre-back.
Aaron Wan-Bissaka and Luke Shaw are nailed-on wing-backs unless they suffer an injury, though David De Gea missed the trip to Palace after returning to Spain for the birth of his child.
There is no time frame on De Gea’s return with Solskjaer keen to give him the time he needs with his new daughter, so Dean Henderson could have a run to try and stake a claim to be United’s new No1 goalkeeper.
Man United predicted lineup (4-2-3-1): Henderson; Wan-Bissaka, Lindelof, Maguire, Shaw; McTominay, Fred; James, Fernandes, Rashford; Martial
Injury list: Pogba, Jones, Mata
Doubts: De Gea, Van de Beek, Martial, Cavani