It is the Dutch who hold the advantage as they welcome their neighbours to Amsterdam, sitting pretty atop Group A4 with a three-point lead.
Belgium must win and recover a three-goal swing to reach the Nations League finals having suffered a shock 4-1 defeat to Netherlands earlier in the competition, with tiebreakers primarily decided on head-to-head records.
Both sides will also use this game to finalise their World Cup preparations, with kick-off in Qatar just a couple of months away.
Here are all the details for tuning in...
Where to watch Netherlands vs Belgium
TV channel: In the UK, Premier Sports 2 will broadcast the game with coverage starting at 7.35pm BST ahead of a 7.45pm kick-off.
Live stream: Those with a Premier Sports subscription can also watch the action unfold online via the Premier Player.