It is understood 30-year-old Shelvey will be out of action for around 12 weeks following the procedure at the weekend.
Shelvey, who had returned to Tyneside following his summer break in excellent shape after working with a personal trainer in Turkey, suffered the injury during the club’s friendly defeat by Benfica in Portugal on 26 July.
The development will come as a major blow to a man who revealed during the closed season that he needs to make just three more senior appearances to trigger a contract extension.
Shelvey was a key member of the side who fought their way to Premier League safety under Howe last season having forced his way back into the team in the wake of Steve Bruce’s departure.
The excellence of January signing Bruno Guimaraes and Sean Longstaff’s return to form will mitigate his absence to an extent, but the variety provided by a midfielder described at the weekend by Howe as “unique” will be missed.
Shelvey’s misfortune may cement 19-year-old Elliot Anderson’s place in the squad at St James’ Park, with the prospect of another loan move after his hugely successful spell at Bristol Rovers last season seemingly having receded further.