American point guard Jordan Farmar proved inspirational for the Israelis, scoring 27 points as Madrid were handed their first loss in the competition this season.
Barcelona , by contrast, were in complete control of their game in Russia against Unics Kazan , winning 93-65.
Erazem Lorbek top-scored for the visitors, scoring 24 points in the rout.
Barcelona remain unbeaten in Group D and boast a better points difference than Siena, who have also triumphed in their first three games.
Brose Baskets of Germany lost a thriller at home to Unicaja Malaga 78-79, with Joel Freeland of Britain providing 18 points and seven rebounds for the visitors.
Bilbao 's mixed start to their Group A campaign continued with a 78-69 defeat at the hands of Italian outfit Cantu .
Olimpia Milan had a day to forget, losing a low-scoring game 54-62 to Efes Pilsen in front of their home crowd. The defeat leaves them fifth in Group C while Efes Pilsen climb to second.
Fenerbahce won a nip-and-tuck clash against French visitors Nancy 90-86. It was a much-needed victory for the hosts, who had been winless from their first two games.
There was a first win too for Partizan who held off Belgian side Spirou to record a 91-81 triumph.