The LaLiga side hold a three-point advantage in Group E going into the game, having claimed a 1-0 win at Old Trafford to open the competition back in September.
With head-to-head records and then goal difference the tiebreaker in Europa League groups - La Real currently hold the advantage in both - United need a two-goal win in Spain to claim top spot.
Finishing first would be vital for either side as it would provide a bye for the round-of-32 knockout between the runners-up and the teams eliminated from the Champions League.
Date, kick-off time and venue
Real Sociedad vs Manchester United is scheduled for an 5.45pm GMT kick-off on Thursday November 3, 2022.
Reale Arena - better known as Anoeta - in San Sebastian will host the match.
Where to watch Real Sociedad vs Manchester United
TV channel: In the UK, the match will be televised live on BT Sport 1, with coverage beginning at 5.15pm.
Live stream: BT Sport subscribers will also be able to watch the action online via the BT Sport website or app.
Live blog: You can follow all the action via Standard Sport’s live blog.
Real Sociedad vs Manchester United team news
Real Sociedad XI: Remiro; Gorosabel, Le Normand, Pacheco, Rico; Mendez, Zubimendi, Merino, Marin; Sorloth, Carlos Fernandez.
Subs: Sola, Illarramendi, Zubeldia, Elustondo, Zubiaurre, Guevara, Navarro, Turrientes, Gonzalez, Marrero, Karrikaburu, Magunacelaya.
Manchester United XI: De Gea; Dalot, Lindelof, Martinez, Shaw; Casemiro, Eriksen; Garnacho, Fernandes, Van de Beek; Ronaldo.
Subs: Dubravka, Vitek, Malacia, Maguire, Wan-Bissaka, Fred, McTominay, Iqbal, Pellistri, Elanga, Rashford, Shoretire.
Real Sociedad vs Manchester United prediction
Sociedad are pretty low scorers this season while United have rarely hit full stride, so expect a nervy match-up in northern Spain.
A 1-0 United win.
Head to head (h2h) history and results
In five meetings including two goalless draws, a total of seven clean sheets have been kept between these two teams.
Real Sociedad wins: 1
Manchester United wins: 2
Real Sociedad vs Manchester United match odds
Real Sociedad: 12/5
Manchester United: 6/5
Odds via Betfair (subject to change).