Blades are now a daunting 15 points from safety after suffering defeat to champions Liverpool at the weekend.
Dean Smith has guided Villa to the periphery of the hunt for a Champions League place, while they are certainly in the mix for a Europa League spot, but they must continue to cope without their talisman.
Meanwhile Chris Wilder has cast doubt over his future at the club, but insists he does want to stay: “I don’t know. We always plan short, medium and long term, but that plan is determined by other people than me. I’ve not had those conversations. I think they should be happening, but they’re not happening.
“Yes, definitely,” Wilder added when pushed over whether he wants to be in charge next season. “If we stick to the plan. The plan, as always, was to leave a legacy, change things off the pitch, which need changing, and stick with the players we’ve invested in and add a couple and try to bounce back - simple as that.”
Here’s everything you need to know about the game at Bramall Lane:
When is it?
The fixture will kick-off at 6pm GMT at Bramall Lane in Sheffield.
How can I watch it?
The match is live on BT Sport 1 / BT Sport Ultimate with coverage starting from 17:30 GMT.
Sheffield United XI: Ramsdale; Ampadu, Jagielka, Bryan; Baldock, Lundstram, Norwood, Fleck, Stevens; McGoldrick, Brewster
Aston Villa XI: Martinez; Ahmed El Mohamady, Konsa Ngoyo, Mings, Targett; McGinn, Nakamba, Ramsey; Traoré, Watkins, El Ghazi
Sheffield United: 11/4
Aston Villa: 21/20
Villa showed mental strength to come away with the three points against Leeds without Grealish and that should carry over here, with Smith building something special at Villa Park. Despite Grealish out again, we’ll lean towards an away win here, with Blades starting to lose hope they can pull off the great escape with games running out and Wilder not showing promising signs about his future, which could impact the team on the pitch.