Both clubs are off to dismal starts to the season, losing each of their opening four games, and are already looking at a fight to stay in the top flight.
Fulham's defensive woes have cost them dear with 11 goals conceded, and Scott Parker will be hoping that some late additions in the transfer window can have an immediate impact.
The Blades, meanwhile, have found their woes to be at the other end of the pitch, with David McGoldrick's consolation effort against Arsenal the only League goal they have mustered so far this season.
Date, time and venue
Sheffield United vs Fulham is scheduled for a 12:00pm BST kick-off today on Sunday, October 18.
The match will be behind closed doors at Bramall Lane with no fans due to be present due to government guidelines regarding coronavirus.
How to watch
TV channel: The match will be shown live via pay-per-view on BT Sport Box Office at a cost of £14.95.
Chris Wilder could give a debut to Rhian Brewster following his move from Liverpool after Oliver Burke and David McGoldrick picked up knocks on international duty.
Joachim Andersen and Ruben Loftus-Cheek are among the new arrivals who could come straight into contention for Fulham.
Prediction: Sheffield United 2-0 Fulham
The international break might have come at just the right time for the Blades and Brewster's arrival should bring some much-needed cutting edge in front of goal.
Head to head (h2h) history and results
The two sides' movements up and down the divisions means they have not actually met in the top flight since the 2006/07 season. The last time they were in the same tier was during the 2017/18 Championship season, and Fulham won a 5-4 thriller.
Betting odds and tips
- Sheffield United to win: 6/5
- Fulham to win: Between 14/5 and 3/1
- Draw: 12/5
- Rhian Brewster to score: Between 5/2 and 13/5
Odds courtesy of Betfair Exchange. Click here to find out more.
We may earn commission from some of the links in this article, but we never allow this to influence our content. This revenue helps to fund journalism across The Evening Standard.