While Erik ten Hag’s side have certainly shown a huge amount of progress in the Premier League of late, they lost on their first European outing of the season and the pressure is on.
A trip to Transnistria certainly looks an arduous one and Sheriff have previous when it comes to pulling off big results, namely beating Real Madrid in last season’s Champions League.
Lose this and United really are up against it in the group stages, which would surely be seen as a huge disappointment.
Where to watch FC Sheriff vs Manchester United
TV channel: The match will be televised on BT Sport 2, with coverage starting at 5.15pm.
Live stream: BT Sport subscribers will be able to watch the match online via the BT Sport website or app.
Live blog: You can follow all the action via Standard Sport’s live blog.