The 15-year-old stunned players, pundits and fans alike when she made her Grand Slam debut at Wimbledon, reaching the fourth round where she was beaten by eventual champion Simona Halep.
The highly-rated youngster, who prefers to be called Coco Gauff, is one of five teenagers given wildcards at Flushing Meadows.
Americans Caty McNally, Whitney Osuigwe and Katie Volynets - all aged 17- and France's 16-year-old Diane Parry were also given a path to the main draw.
Australian Samantha Stosur, US Open champion in 2011, will be making her 15th appearance in the main draw.
The 35-year-old, who last reached a Grand Slam singles semi-final in 2016 at Roland Garros, was also a doubles champion in New York in 2005.
"Parry and Stosur earn their entry via the USTA's reciprocal wildcard arrangement with the French Tennis Federation and Tennis Australia," the tournament's organisers said in a statement.
In the men's draw, American Jack Sock is one of the high-profile names to have been handed a wildcard.
The 26-year-old, who was sidelined for six months after sustaining a thumb injury at the Australian Open, is looking to maintain his streak of playing in every U.S. Open main draw since 2010.
The tournament begins on August 26, with the men's singles final taking place on September 8.
Additional reporting from Reuters.