Debris from the attack hit a high-rise residential building which caused a fire. The blast wave also damaged surrounding residential buildings.
Emergency services said 27 people, including three children, were wounded, but the fire had been rapidly put out and 12 people were rescued from the building.
“As a result of the air fight, debris from one of the drones fell onto a high-rise apartment, causing a fire,” the southern military command’s spokesperson Natalia Humeniuk said of the attack on Odesa.
A couple were among those killed as well as a man who been outside at the time of the attack.
Russian forces used Iranian-made drones to attack the region, all of which were shot down by Ukrainian forces, according to reports.
Russia also fired missiles and attack drones at the central Ukrainian region of Poltava overnight, inflicting “some damage of infrastructure and equipment” at the Myrhorod military airfield, according to the regional governor.
The attack using ballistic and cruise missiles also damaged eight private residential homes and several vehicles, but no casualties were reported.
Ukraine also shot down two drones over the Dnipropetrovsk region where no damage was reported, its governor Serhiy Lysak said.