The Swede was rated as 50/50 ahead of the game at Selhurst Park, but is not fit enough to even make the bench in south London.
Bryan Gil keeps his place as a result, after making his full Premier League debut in Sunday's dismal defeat to Aston Villa.
Rodrigo Bentancur remains out with a adductor injury sustained at the World Cup, while Yves Bissouma is suspended after picking up his fifth yellow card of the season against Villa. Oliver Skipp comes into the midfield.
Eric Dier returns, and Antonio Conte opts for Clement Lenglet over Ben Davies at left centre-half.
Matt Doherty has leapfrogged Emerson Royal at right wing-back since the World Cup and keeps his place, with Conte likely to ring the changes for the FA Cup third-round tie against Portsmouth on Saturday.
Starting XI: Lloris; Romero, Dier, Lenglet; Doherty, Hojbjerg, Skipp, Perisic; Gil, Kane, Son.
Subs: Forster, Davies, Sanchez, Tanganga, Sessegnon, Royal, Spence, Sarr, White