After failing to qualify for the last World Cup, the United States will be keen to make an impact this time around in Qatar.
The USA will host the next tournament in 2026 with Canada and Mexico and, as a result, investment and interest in the sport is growing.
Coach Gregg Berhalter is under pressure to succeed.
Here’s everything you need to know about the United States…
Coach: Gregg Berhalter. Had a season at Crystal Palace during his playing days. Took charge of USA in 2018.
Captain: Christian Pulisic. The Chelsea forward is their talisman.
Star player: Pulisic. Already has over 50 caps and averages nearly a goal every other match.
One to watch: Yunus Musah. Once on Arsenal’s books as kid, the midfielder is now thriving at Valencia.
World ranking: 16th.
Best thing about them: Plenty of exciting young players, like Musah and Timothy Weah.
Worst thing about them: For a country that big, they should be doing far better.
Their prospects in three words: Fight for second.
Fixtures (all times GMT)
November 21 vs Wales (7pm)
November 25 vs England (7pm)
November 29 vs Iran (7pm)
Squad in full
Goalkeepers: Ethan Horvath, Sean Johnson, Matt Turner
Defenders: Cameron Carter-Vickers, Sergino Dest, Aaron Long, Shaq Moore, Tim Ream, Antonee Robinson, Joe Scally, DeAndre Yedlin, Walker Zimmerman
Midfielders: Brenden Aaronson, Kellyn Acosta, Tyler Adams, Luca de la Torre, Weston McKennie, Yunus Musah, Cristian Roldam
Forwards: Jesus Ferreira, Jordan Morris, Christian Pulisic, Gio Reyna, Josh Sargent, Tim Weah, Haji Wright