Jordan Henderson comes into midfield too - it was thought that Jude Bellingham would drop out but Mason Mount is the one to make way.
Kyle Walker comes into the team at right-back in a back four. That means Kieran Trippier drop outs, as Southgate favours continues with Luke Shaw on the opposite flank.
The Three Lions are all-but secure of their route to the last-16, with only a four-goal loss to Wales seeing them head home early. Should they top the group, they will play Senegal next.
England Training Session for FIFA World Cup 2022 Qatar | 28th November 2022
“We want to win football matches and we want to try to top the group if we can,” Southgate told reporters on the topic of his selection.
“So we’ve got to make sure there is some consistency in what we do and our performances are healthy. There is always a balance of finding game time for players. But the priority is to win games, we have to win football matches.”
For Wales, Joe Allen starts in midfield following a hamstring injury. He returned as a substitute in the defeat to Iran last time out.
Wayne Hennessey is suspended after his red card in that match, meaning Danny Ward replaces him in goal.
Dan James comes into the side in what appears to be a front three as Wales opt for a back four, suggesting a bit more attacking ambition will be on show.
Wales XI (4-3-3): Ward, Williams, Mepham, Rodon, Davies, Ampadu, Allen, Ramsey, Bale, James, Moore
England XI (4-3-3): Pickford; Walker, Stones, Maguire, Shaw; Bellingham, Rice, Henderson; Foden, Rashford, Kane.