That's because they currently have a one-goal edge over Watford in 17th, but there is very little wiggle room.
The Hornets, who face Arsenal, have also scored less, so a two-goal swing in the goal difference department will be required.
David Moyes has his West Ham side in fine form, but with safety assured and several signature performances in the last month, the motivation might be lacking in comparison to Dean Smith's side.
Here's how you can watch the game on television or on a live stream.
When is it and what time is kick-off?
The match will begin at 4pm on Sunday 26 July at the London Stadium.
How can I watch it online and on TV?
The match will be broadcast live on BT Sport 1, BT Sport Extra 1 and BT Sport Ultimate, you can find a live stream for the game through the BT Sport app to watch on mobile devices.
What is the team news?
Jarrod Bowen and Aaron Cresswell both picked up minor injuries in the draw at Manchester United, so both players will need to pass fitness tests to feature here. Felipe Anderson is back from a hamstring issue and could pick up some minutes here after remaining on the bench at Old Trafford.
Ahmed Elmohamady (hamstring) is out, while Neil Taylor (hamstring) is back in contention. Dean Smith's main decision may be whether to move Ezri Konsa to right-back over Frederic Guilbert, with Kortney Hause filling in at centre-back.
West Ham XI: Fabianski, Fredericks, Diop, Ogbonna, Johnson, Rice, Soucek, Noble, Fornals, Bowen, Antonio
Aston Villa XI: Reina, Guilbert, Konsa, Mings, Targett, McGinn, Douglas Luiz, Hourihane, Trezeguet, Samatta, Grealish
What are the odds?
West Ham: 2/1
Aston Villa: 13/10
Villa simply want this more and David Moyes's West Ham have already secured both survival and a number of impressive performances against top sides to build from next season. Dean Smith's side should take this one, but it might be tense and nervy as news filters through from the Emirates and Goodison Park. 0-1.