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It’s a tough encounter for David Moyes and his team and they might feel harshly rewarded with it having knocked out Manchester United in the third round. City, meanwhile, saw off Wycombe Wanderers with ease.
The Hammers have impressed all season long, including in Europe, and it could well be a very tight encounter if Moyes opts to go full strength - though of course Pep Guardiola’s side have great quality in depth.
City have won the last four editions of this cup and are seeking a record-breaking fifth this term.
Here’s everything you need to know ahead of the match.
When is the match?
The game kicks off at 7:45 pm on Wednesday, 27 October at the London Stadium.
Where can I watch it?
This fixture is not scheduled for live broadcast on UK TV.
WHU - Areola, Johnson, Dawson, Diop, Cresswell, Masuaku, Soucek, Noble, Lanzini, Vlasic, Yarmolenko
MNC - Steffen, Walker, Stones, Ake, Zinchenko, Fernandinho, Gundogan, De Bruyne, Mahrez, Sterling, Palmer
West Ham 33/5
Man City 1/2
If the Hammers go with a strong line-up and City rotate, they could be the ones to finally end City’s dominance of this competition - but that’s a big ask considering their European exploits too. Big changes to the team could make it one-way traffic. West Ham 1-3 Man City.