The Hammers have looked impressive this season, but failed to break down Aston Villa on Monday night as they drew 0-0.
United ended their three game winless run by beating Leicester at home last Saturday, but have not scored more than once in a game this season since the 4-0 win over Chelsea on the opening weekend.
Ole Gunnar Solskjaer rotated heavily against FC Astana as United laboured to a 1-0 win, so much of his side should be well rested when they travel down to London.
We have everything you need to know ahead of the match.
United have been turgid in attacking areas this season, and lack quality creators from midfield with Paul Pogba out injured.
The Hammers’ full-backs love to push on, but United may struggle to exploit them on the counter if Dan James and Mason Greenwood don’t start. Sebastian Haller versus Harry Maguire will be an interesting spectacle in both boxes.
Manuel Lanzini’s creativity will be sorely missed if he fails his fitness test, so this game could easily peter out into a draw.
West Ham 0-0 Manchester United
West Ham 9/4
When is it?
The game kicks off at 2pm on Sunday September 22.
How can I watch it?
Sky Sports Premier League and Main Event will have coverage of the game, with build-up starting an hour before kick off.
Sky customers can also live stream the match using the Sky Go app.
Manuel Pellegrini has confirmed that Manuel Lanzini has a small issue and will be assessed ahead of the match, whilst Arthur Masuaku is suspended after being sent off against Villa.
After impressing in the match against FC Astana, Mason Greenwood is pushing for a start with Anthony Martial definitely out and Dan James doubtful.
Luke Shaw and Paul Pogba are also unavailable for Solskjaer.
West Ham – Fabianski; Fredericks, Diop, Ogbonna, Cresswell; Rice, Noble; Yarmolenko, Lanzini, Anderson; Haller
Manchester United – De Gea; Wan-Bissaka, Lindelof, Maguire, Young; Matic, McTominay; Pereira, Mata, Lingard; Rashford
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