Extending a run of one defeat in seven games is the priority for the Hammers after downing Bournemouth in confident fashion last time out.
Already qualified out of Group B, West Ham also have a 100 per cent record in the competition but face a Danish side sat second in the table and still technically able to leapfrog them at the top with a big turnaround in the final two matchdays.
Date, kick-off time and venue
West Ham vs Silkeborg is scheduled for an 8pm BST kick-off on Thursday, October 27, 2022.
London Stadium will host the match.
Where to watch West Ham vs Silkeborg
TV channel: The match will be televised on BT Sport 2 with coverage starting at 7.45pm.
Live stream: BT Sport subscribers will be able to watch the match online via the BT Sport website or app.
West Ham vs Silkeborg team news
Nayef Aguerd could make his debut for the Hammers after three months out with an ankle injury.
Maxwel Cornet will not feature after a setback in his recovery while Lucas Paqueta and Craig Dawson remain unavailable.
West Ham vs Silkeborg prediction
Silkeborg threatened an upset in Denmark but should find themselves outgunned in east London.
A 2-0 West Ham win.
Head to head (h2h) history and results
The 3-2 win for the Hammers in September was their only competitive meeting.