Bowen sat out Thursday night’s Europa Conference League victory over Silkeborg, which secured top spot in Group B and a bye into the last-16 in March.
David Moyes revealed after that game that Bowen had suffered an ankle knock and would be assessed on Friday but speaking to the press ahead of the trip to Old Trafford the Scot was unable to say whether the winger would be fit.
“There’s a bundle there, isn’t there? I think every club is the same with the amount of fixtures we’ve all got, there’s injuries and knocks,” said Moyes. “Hopefully, we’ve come through last night not too bad.
“We didn’t have Jarrod, he had an ankle injury. He’s done a little bit of running on the grass today, so we will need to see how he is.”
Maxwel Cornet is not fit having suffered a setback in his return from a calf problem, while Craig Dawson returns from a dead leg against Anderlecht earlier this month.
Moyes did offer clarity on Brazilian midfielder Lucas Paqueta, whoever, who has been ruled out of the United fixture but could return next week.
West Ham XI: Fabianski; Kehrer, Zouma, Dawson, Cresswell; Rice, Soucek; Bowen, Downes, Benrahma; Scamacca.
Subs: Areola, Johnson, Coufal, Fornals, Antonio, Lanzini, Ogbonna, Coventry, Emerson.