Chelsea midfielder Jorginho missed a last-minute penalty as Italy failed to take the chance to qualify for the 2022 World Cup.
Roberto Mancini’s side drew 1-1 with Switzerland, meaning the two sides are still level on points going into the final round of matches.
Italy’s goal difference is two better than that of Switzerland, who host Bulgaria on Monday evening.
Northern Ireland, who Italy travel to face in their final qualifier, moved up to third in Group C with a 1-0 win over Lithuania.
Benas Satkus’ own-goal was enough for the three points at Windsor Park, but their World Cup hopes were already extinguished last month.
Elsewhere in Europe, Poland eased to a 4-1 win over Andorra, who had a man sent off inside the first minute.
Robert Lewandowski scored twice, and the result effectively confirms Poland’s place in the play-offs after Albania’s defeat to England.
They will join Scotland, after they secured their spot in the play-offs earlier in the night.
A 2-0 win over Moldova took Steve Clarke’s side beyond the reach of Israel and Austria, and kept the country’s hopes of a first World Cup appearance since 1998 alive.
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