The Gunners played Tottenham in the north London derby last Saturday and take on Liverpool in another huge Premier League fixture at Emirates Stadium on Sunday.
Granit Xhaka keeps his place from Saturday’s win over Spurs, as do Gabriel and Gabriel Martinelli, but apart from that it’s a heavily rotated side.
Eddie Nketiah leads the line as expected, while Marquinhos also gets his chance again in Europe. Takehiro Tomiyasu, Kieran Tierney and Fabio Vieira will be looking to push their cases for more first-team starts.
There is no Reiss Nelson in the starting lineup though, despite the Arsenal boss suggesting ahead of the match he needed minutes.
“Well obviously after the spell that he (Nelson) had last year on loan, we wanted him back to see if there is any changes, there is a prospect that we can really take to the next level,” said Mikel Arteta on Wednesday.
“I think the potential is there, we always hang in there because we see something in Reiss that is special.
“Obviously he is part of our academy system. Now he is going to have an opportunity. He has been out for almost three months with an injury. He’s back now. He’s fully fit and he is ready to play, he just needs minutes.”
Gabriel Jesus, Bukayo Saka and Martin Odegaard are among those waiting on the bench if required at the Emirates.
Arsenal XI: Turner; Tomiyasu, Holding, Gabriel, Tierney; Vieira, Lokonga, Xhaka; Marquinhos, Nketiah, Martinelli.
Subs: Hein, White, Cedric, Saliba, Partey, Cirjan, Smith, Saka, Nelson, Odegaard, Jesus
Thursday 8pm BST, BT Sport
Venue: Emirates Stadium