The Cameroon forward was forced off during the defeat at Brighton on Wednesday night and is now in a race against time to be fit for the Africa Cup of Nations next month.
His absence is a huge blow for the Bees with the banned Ivan Toney also not available until the middle of January.
Christian Norgaard has served his ban so will come back in, but that's where the good news ends for Thomas Frank.
Josh Dasilva and Mathias Jensen will be assessed ahead of the game.
Doubts: Josh Dasilva and Mathias Jensen
Injuries: Bryan Mbeumo, Kristoffer Ajer, Nathan Collins, Rico Henry, Kevin Schade and Aaron Hickey
Banned: Ivan Toney
Time and date: 3pm GMT on Saturday December 9, 2023
Venue: Bramall Lane