Emma Hayes’ side lead 1-0 at the halfway stage of the last-eight tie after victory in France, with Guro Reiten’s brilliant strike proving to be the only goal of the match.
Defending champions Lyon, who have won this competition in six of the last seven seasons, therefore have work to do in London if they are to avoid more disappointment against English opposition, having been beaten 5-1 by Arsenal in the group-stage.
Chelsea come into this match off the back of a rare defeat, after they were beaten by Manchester City last time out. Should the Blues and Arsenal win their games in hand, the top four in the WSL will be separated by just two points.
Where to watch Chelsea vs Lyon
TV channel: In the UK, the game will be availabe to watch via DAZN, with kick-off at 8pm BST.
Live stream: The DAZN website will broadcast the game online and a free stream is also available via DAZN’s YouTube channel.
Live blog: You can also follow all the action LIVE via Standard Sport’s matchday blog, featuring expert analysis from Simon Collings at Stamford Bridge.