Chelsea will also withhold Romeo Lavia from making his Chelsea debut as they build up his fitness with a training programme.
They have joined Christopher Nkunku and Wesley Fofana in the Blues treatment room, after they suffered serious knee injuries during pre-season, with Armando Broja, Benoit Badiashile and Marcus Bettinelli completing a hefty nine-man injury list.
It leaves Pochettino with limited options in attack which may see a returning Noni Madueke make his first start since sustaining a hamstring problem in pre-season.
Pochettino said: “Moises is ready to start, Lavia is not. After [the fitness coaches] assessed him, he needs a few weeks to be ready to be involved with the team. He is reconditioning now and working to try to catch the team and his teammates.
“For Romeo, we need to wait a few weeks until he is involved with the team.”
Starting Chelsea XI: Sanchez; Gusto, Disasi, Silva, Colwill; Caicedo, Enzo; Sterling, Gallagher, Chilwell; Jackson
Time and date: 8pm BST on Friday, August 25, 2023
Venue: Stamford Bridge