It has been 32 years since the teams last met, with The Hatters running out 1-0 winners in the old First Division.
Arsenal were serious title contenders then and are serious title contenders again now as they look to move five points clear at the top, at least for now, with a victory.
Date, kick-off time and venue
Luton vs Arsenal is scheduled for an 8.15pm GMT kick-off tonight, Tuesday, December 5, 2023.
The match will take place at Kenilworth Road.
Where to watch Luton vs Arsenal
TV channel: In the UK, the match will be televised live on Amazon Prime Video.
Live stream: Fans can also catch the game live online via the Amazon Prime Video app and website.
Live blog: You can follow all the action tonight via Standard Sport’s live blog, with expert analysis from Simon Collings at the ground.
Luton vs Arsenal team news
Loanee Albert Sambi Lokonga will not be able to face his parent club, but would be unlikely to feature anyway due to fitness issues.
Luton vs Arsenal prediction
Luton have started picking up points after a tough start, but Arsenal will surely have too much for them on Tuesday night especially given the Hatters' latest injuries.
Mikel Arteta will be tempted to rotate with Aston Villa to come at the weekend as the fixtures continue to come thick and fast, but the squad will have plenty in the tank to rack up another win.
Arsenal to win, 2-0.
Head to head (h2h) history and results
This is the first Premier League meeting between the two teams, with their last clash coming in the old First Division in 1991.
Luton wins: 10
Arsenal wins: 27
Luton vs Arsenal match odds
Odds via Betfair (subject to change).