The Red Devils require at least a two-goal victory in San Sebastian to secure top spot in Group E, handing them a bye for the tricky round-of-32 stage against a team finishing third in this year’s Champions League groups.
Anthony Martial misses out again having last featured in the win at Everton almost a month ago before being sidelined with a back issue, his third injury problem of the campaign so far.
United confirmed the French striker’s return to training ahead of the game, though it has come too soon for him.
Antony sat out the weekend win over West Ham with a knock and does not travel while Victor Lindelof was ill. The latter, however, is in the squad alongside Aaron Wan-Bissaka.
Jadon Sancho misses out through illness and a lot will likely fall upon Cristiano Ronaldo up front.
Given the important nature of the game, Erik ten Hag has unsurprisingly picked a strong starting line-up, although in attack he has opted for Donny van de Beek and Alejandro Garnacho.
Manchester United XI: De Gea; Dalot, Lindelof, Martinez, Shaw; Casemiro, Eriksen; Garnacho, Fernandes, Van de Beek; Ronaldo.
Subs: Dubravka, Vitek, Malacia, Maguire, Wan-Bissaka, Fred, McTominay, Iqbal, Pellistri, Elanga, Rashford, Shoretire.