The first Manchester derby of the season takes place at Old Trafford.
United are searching for a win to kickstart their stuttering season, while City will be looking to respond to victories by Tottenham and Arsenal.
Here’s all you need to know about the game…
Date, kick-off time and venue
Old Trafford in Manchester will host.
Where to watch Man United vs Man City
TV channel: The game will be broadcast on Sky Sports Main Event, Sky Sports Premier League and Sky Sports Ultra HDR. Coverage starts at 3pm BST.
Live stream: Subscribers will be able to watch on a live stream via the Sky Go app.
Live blog: You can also follow the game via Standard Sport's live matchday blog!
Man United vs Man City team news
Man United vs Man City prediction
It’s difficult to look past City even despite the success United have had in this fixture in recent memory. Ten Hag’s team have just not convinced all season.
Man City to win 3-1.
Head to head (h2h) history and results
Only once in the last 16 Manchester derbies has the score ended in a draw.
Man United wins: 78
Man City wins: 59
Man United vs Man City latest odds
Man United to win: 4/1
Man City to win: 4/6
Odds via Betfair and subject to change.