The England international missed Wednesday's dramatic six-goal draw away at Galatasaray in the Champions League due to a one-game European suspension that followed his controversial sending off in Copenhagen.
Christian Eriksen, Casemiro and Lisandro Martinez are longer-term absentees, while Mason Mount is suffering from a calf injury as his frustrating start to life as a United player continues. Tyrell Malacia has suffered a setback in training.
Erik ten Hag turns back to young Kobbie Mainoo, too. Praised for his performance at Goodison Park, the midfielder started on the bench for the draw in Turkey earlier this week. Jadon Sancho is still unavailable, meanwhile.
United are a point ahead of Newcastle and are in decent form in a Premier League context, though have struggled against the more competitive sides this season.
A defeat on the road would pile more pressure on Ten Hag, with chances of Champions League progression looking very slim heading into the final matchday.
Injured: Eriksen, Casemiro, Martinez, Mount, Evans, Malacia, Diallo
Date and time: 8pm GMT on Saturday December 2, 2023
Venue: St James’ Park