Roma moved up to fifth after a comfortable win, with Lorenz Pellegrini turning in a corner to open the scoring after just two minutes.
Dybala doubled the advantage in the 23rd minute and all but ended the match as a contest six minutes into the second half, scoring from the penalty spot after Andrea Petagna handled in the box.
⏹️ THREE MASSIVE POINTS! 🤍❤️ pic.twitter.com/ieIRGPml5k
The suffering was not yet over for former Roma boss Claudio Ranieri, with Dean Huijsen heading in a fourth just before the hour.
In Spain, a first-half brace from Youssef En-Nesyri saw Sevilla win 2-1 at Rayo Vallecano, earning only their fourth league win of the season to give themselves a three-point cushion above the relegation zone.
Although En-Nesyri’s 19th-minute opener was cancelled out by Isi Palazon 10 minutes later, the Morroccan struck again on the stroke of half-time.