The 49ers impressed in a 42-19 thrashing of the Philadelphia Eagles at the Linc. Brock Purdy threw four touchdowns and Deebo Samuel scored three times along with 116 receiving yards. With their roster healthy, San Francisco is on a four-game win streak outscoring opponents 134-49.
Geno Smith threw three touchdowns to DK Metcalf as the Seahawks gave the Dallas Cowboys a scare, but ultimately lost 41-35. Their 35 points were the most they've scored since Week 2 and 3 when they put up 37 against the Detroit Lions and Carolina Panthers, both wins.
San Francisco won the first matchup this season 31-13 in Seattle. Christian McCaffrey had 19 carries for 114 yards and two touchdowns. Smith was sacked six times and the Seahawks' only touchdown was a pick-six from Jordyn Brooks.
Will the Seahawks get revenge? Or will the 49ers extend their three-game regular season win streak over their division foe?
49ers vs. Seahawks odds, moneyline, over/under
The 49ers are favorites to defeat the Seahawks, according to the BetMGM NFL odds. Looking to wager? Check out the best mobile sports betting apps offering NFL betting promos in 2023, including the new ESPN BET app.
Spread: 49ers (-10.5)
Moneyline: 49ers (-550); Seahawks (+400)
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Steelers vs. Patriots | Falcons vs. Buccaneers | Ravens vs. Rams | Bears vs. Lions | Bengals vs. Colts | Browns vs. Jaguars | Saints vs. Panthers | Jets vs. Texans | Raiders vs. Vikings | 49ers vs. Seahawks | Chiefs vs. Bills | Chargers vs. Broncos | Cowboys vs. Eagles | Dolphins vs. Titans | Giants vs. Packers
Lorenzo Reyes: 49ers 28, Seahawks 21
The 49ers are playing with confidence, swagger and they’re fully healthy. That’s a dangerous combination for the most complete and balanced team in the NFL, but this is a very big number for a division rival. This feels like an overcorrection after San Francisco’s drubbing of the Eagles.
Tyler Dragon: 49ers 31, Seahawks 17
The 49ers made a resounding statement last week in Philadelphia. They should be the top dog in the NFC until further notice. Wide receiver Deebo Samuel scored touchdowns on three consecutive touches against the Eagles. San Francisco is difficult to beat when Samuel, Christian McCaffrey, Trent Williams, George Kittle and Brock Purdy are all healthy. The 49ers beat the Seahawks 31-13 in Week 12. This one won’t be much different.
Safid Deen: 49ers 31, Seahawks 17
The Seahawks rebounded from their Thanksgiving loss against the 49ers against the Cowboys last week and lost a close game. I’m not sure if Seattle has what it takes to keep their season alive against the best team in the NFL for the second time in three weeks.
Victoria Hernandez: 49ers 32, Seahawks 20
The 49ers pulled off an impressive road win last week and made a case for best team in the NFC when everyone's healthy. The Seahawks have shown grit and gave Dallas a scare last week, but they are dealing with their own injuries right now and are on the road. San Francisco has an encore of Thanksgiving and takes this one easily.
Jordan Mendoza: 49ers 34, Seahawks 17
After last week’s demolition of Philadelphia, nobody wants to play San Francisco right now. The 49ers made easy work of Seattle on Thanksgiving, and with the groove the team is in, it’ll be more of the same this time around.
You can view the full list of USA TODAY's NFL expert predictions here.
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This article originally appeared on USA TODAY: Seattle Seahawks at San Francisco 49ers: Game predictions, picks, odds