Antonio Conte is desperate for Spurs to push on after a top-four finish last season returned them to Champions League football.
A plethora of summer signings have arrived to bolster their squad with victory firmly expected of the hosts in north London against a Saints side once again hoping to reach the upper echelons of mid-table.
But Ralph Hasenhuttl must first ensure Southampton’s survival and an opening day win would immediately lift the mood on the south coast.
Here are all the details ahead of the game...
Date, kick-off time and venue
Tottenham vs Southampton is scheduled for a 3pm BST kick-off on Saturday, August 6, 2022.
Tottenham Stadium in London will host the match.
Where to watch Tottenham vs Southampton
TV channel: The match will not be televised live on TV in the UK.
Live blog: You can still follow all the action via Standard Sport’s live blog.
Tottenham vs Southampton lineups and team news
Tottenham XI: Lloris, Romero, Dier, Davies, Emerson, Hojbjerg, Bentancur, Sessegnon, Kulusevski, Son, Kane
Subs: Doherty, Sanchez, Gil Salvatierra, Perisic, Forster, Spence, Lucas Moura, Lenglet, Bissouma
Southampton XI: Bazunu, Valery, Salisu, Bednarek, Walker-Peters, Ward-Prowse, Romeu, Lavia, Aribo, Djenepo, Adam Armstrong
Subs: McCarthy, Stephens, Adams, Redmond, Perraud, Stuart Armstrong, Elyounoussi, Diallo, Kotchap
Tottenham vs Southampton prediction
A straightforward home game would be an ideal start to the campaign for Antonio Conte but don’t expect the goals to glow too fluidly on the first weekend.
A 1-0 Spurs win.
Head to head (h2h) history and results
Spurs failed to win either of last season’s meetings with their opponents this weekend.
Tottenham wins: 85
Southampton wins: 65