Richarlison starts for Tottenham against West Ham, with Heung min-Son dropped to the bench.
Son has been struggling for form and Richarlison comes in to play alongside Harry Kane and Dejan Kulusevski in a front three for Spurs.
Olivier Skipp starts alongside Pierre-Emile Hojbjerg in midfield.
Emerson Royal starts ahead of new signing Pedro Porro at right-wing back.
Cristian Romero served a one-game domestic ban at Leicester last weekend but returns to the team.
Antonio Conte remains in Italy was recovers from gallbladder surgery, so assistant coach Cristian Stellini will again lead the team.
Rodrigo Bentancur has been ruled out for the rest of the season and Yves Bissouma, Ryan Sessegnon and goalkeeper Hugo Lloris remain long-term absentees.
Ben Davies is at left wing-back, with Ivan Perisic on the bench.
Confirmed Tottenham XI: Forster; Romero, Dier, Lenglet; Royal, Hojbjerg, Skipp, Davies; Richarlison, Kulusevski, Kane
Subs: Austin, Sanchez, Son, Perisic, Danjuma, Porro, Tanganga, Moura, Sarr