They started their campaign with a 1-1 draw with Wales, Gareth Bale cancelling out Timothy Weah's 36th-minute opener.
Coach Gregg Berhalter admitted his team need to be more clinical if they are to stand a chance of reaching the knockout stage at the World Cup after they produced a lively display against England on Friday but ultimately fired blanks.
The US dominated play for long periods but were unable to convert a flurry of first-half chances and played out a second straight draw, after Monday's 1-1 stalemate with Wales.
Berhalter's side are third in Group B with two points and would go through to the last 16 for the fifth time since 1994 with a win over Iran in their final group game on Tuesday.
"The final product still could be better... I'm overall pleased with the performance of the group, most importantly the belief of this group because that never wavered," Berhalter said.
"What I saw pre-game was a team that was extremely focused on getting results. In the end, it sets up our first knockout game of this World Cup and that's going to be a focus of ours.
"We played with a ton of spirit but we're going to have to be up for it [against Iran]. We want a chance to advance... We know it's going to be a difficult game, and I'm looking forward to the opportunity."
Group stage fixtures
USA 1 Wales 1, Monday November 21
England 0 USA 0: Friday November 25
Iran vs USA: Tuesday November 29, 7pm (GMT), 10pm local time, 2pm (ET), 1pm (CT) and 11am (PT) (Al Thumama Stadium, Doha)
Latest USA news from Qatar
Tyler Adams, Yunus Musah and Weston McKennie ran the show in midfield and the Americans were unlucky not to be ahead at the break, with Christian Pulisic rattling the crossbar with a fierce left-footed strike.
England, who crushed Iran 6-2 in their group opener, were outplayed by the vibrant albeit inexperienced Americans, who returned to the World Cup stage after eight years, and were loudly jeered by their supporters at the final whistle.
"I guess that's a positive sign when you play for the other team," Chelsea forward Pulisic said. "It was a really solid performance from the team against a good opponent.
"We were a team out there who showed a lot of confidence and battled toe-to-toe... but the job's not even close to done so we've got a lot of work to do."
USA's Group B opponents
Whilst England are the favourites and Wales could cause a group upset for runners-up spot, Iran are the underdogs of Group B. Although a Fifa ranking of 22 suggests they are by no means one of the weakest sides in the competition statistically, preparations have been marred by infighting while head coach Dragan Skocic has been replaced by former manager Carlos Queiroz, who oversaw the team's group stage knock-out in Russia.
As for England, they made a winning start to their 2022 World Cup campaign with an emphatic 6-2 win over Iran.
Bukayo Saka scored twice in his first major tournament appearance since missing his spot-kick in last year's European Championship final defeat to Italy while Marcus Rashford scored within minutes of coming on in a thumping victory that Jude Bellingham, Raheem Sterling and Jack Grealish also scored in.
Before playing the US, Wales had reached the World Cup finals in dramatic style via the qualifying play-offs, after beating an impassioned Ukraine side in Cardiff in June. Victory for Wales' talent-studded golden generation booked them a trip to the nation's second ever World Cup finals – their first since 1958.
World Cup schedule
If USA were to win Group B
The winners of Group B will play the runners-up of Group A – Qatar, Holland, Ecuador, and Senegal – with the Afcon winners their most likely opponents.
France are favourites to win Group D, over Denmark, Tunisia and Australia, and would face the Group C runner-up out of Argentina, Saudi Arabia, Mexico or Poland to win the chance to face USA in the quarter-finals, should Berhalter's men make it out of the last-16 knock-out round.
If USA reached the semi-finals, they could meet either Belgium or Portugal, strong contenders in Group F and H.
If USA were to finish as runners-up in Group B
This would set up a clash between the winner of Group A, and if USA were to beat Holland, they could face Argentina or Denmark in the quarter-finals.
In this scenario, should USA make it to the semi-finals, their opponents might be one of either Spain, Germany, or Brazil, the cream of the crop from Groups E and G, to set up a possible final against France, Belgium, or Portugal in Lusail.
The first two quarter-finals will take place on Friday, December 9, at 3pm and 7pm, and will be played at Education City Stadium and Lusail Iconic Stadium. The remaining quarter-finals are on Saturday, December 10, at 3pm and 7pm, and will be played at Al Thumama Stadium and Al Bayt Stadium.
The semi-finals will take place on Tuesday, December 13 and Wednesday, December 14, at Lusail Iconic Stadium and Al Bayt Stadium, with both matches taking place at 7pm.
The World Cup final will take place on Sunday, December 18 at 3pm at Lusail Iconic Stadium.
Who is in the USA team?
Berhalter named a 26-man team for the tournament, and with an average age of 25 years and 175 days, it is the second youngest of any teams in Qatar. It can be found in full here.