Quite how far they can go while relying on so few players remains to be seen and Goodison Park looks a real test.
It’s also a particularly big game for one Anthony Gordon. Flying at Newcastle now and having left Everton under a cloud almost a year ago, he’s in for quite the reception.
Here’s how to watch all the action live tonight.
Where to watch Everton vs Newcastle
TV channel: Tonight's game will be broadcast live on Amazon Prime Video. Coverage will start at 7pm GMT ahead of a 7:30pm kick-off.
Live stream: Subscribers will be able to watch on a live stream via the Amazon Prime Video website or app.